be of considerable clinical importance

clinical data

And it took over three years, more like five years, to convincingly show the clinical benefit here.""VOA-T333", "2248753"

clinical judgment

issue in clinical practice

address a clinical question

clinical implications

clinical efficacy

be based on a clinical ground

clinical suspicion

confirm a clinical suspicion

clinical evidence

clinical details

clinical importance

clinical differentiation

clinical limitation

be of little clinical importance

be of no clinical significance

clinically important bleeding

be of clinical benefit

clinically-important symptom

be of great clinical importance

do a clinical evaluation of

clinical problem facing

have clinical benefits in preventing

be of clinical benefit in the treatment of

clinical benefit and risk of

question the clinical importance of

Although clinically AEDs have been shown to be effective, it was unclear whether having them publicly available in places like schools, workplaces and sports facilities would improve community survival rates following cardiac arrests."VOA-T292", "2241928"

ICH E1 and ICH E7 describe the overall clinical safety database considerations for chronically administered drugs and drugs used in the elderly.〔【出典】ICHガイドライン 〕

"I think we'll start to have the kind of clinical benefits that you alluded to, you know, more than four months."VOA-T342", "2168416"

It is quite rare that existence of virus can be assumed in a substrate for drug production, with the exception of the substrate of rodent origin, and such suspicious raw material/substrate should not be used for manufacturing drug with a special exceptional case that the drug in question is not available from the other process and is clinically indispensable, and that the information including infectious properties of the virus particle assumed to exist has been clarified.〔【出典】第十六改正日本薬局方（平成23年3月24日　厚生労働省告示第65号）〕

But until now, strong clinical evidence about its effectiveness has not been forthcoming."VOA-T210", "2275125"

Both can provide relevant information on clinical risk assessment.〔【出典】ICHガイドライン 〕

A primary endpoint（s） should reflect clinically relevant effects and is typically selected based on the principal objective of the study.〔【出典】ICHガイドライン 〕

If a surrogate end point （a laboratory measurement or physical measurement or sign that is not a direct measure of clinical benefit） was used as a study end point, this should be justified e.g., by reference to clinical data, publications, guidelines or previous actions by regulatory authorities.〔【出典】ICHガイドライン 〕

A surrogate endpoint is an endpoint that is intended to relate to a clinically important outcome but does not in itself measure a clinical benefit.〔【出典】ICHガイドライン 〕

There should be brief narratives describing each death, each other serious adverse event, and those of the other significant adverse events that are judged to be of special interest because of clinical importance.〔【出典】ICHガイドライン 〕

The acceptability of cell lines containing viruses other than endogenous retroviruses will be considered on an individual basis by the regulatory authorities, by taking into account a risk/benefit analysis based on the benefit of the product and its intended clinical use, the nature of the contaminating viruses, their potential for infecting humans or for causing disease in humans, the purification process for the product （e.g., viral clearance evaluation data）, and the extent of the virus tests conducted on the purified bulk.〔【出典】ICHガイドライン 〕

The acceptability of cell lines containing viruses other than endogenous retroviruses will be considered on an individual basis by the regulatory authorities, by taking into account a risk/benefit analysis based on the benefit of the product and its intended clinical use, the nature of the contaminating viruses, their potential for infecting humans or for causing disease in humans, the purification process for the product （e.g., viral clearance evaluation data）, and the extent of the virus tests conducted on the purified bulk." For example, it is well known that Type A-, R-and C-endogenous particles like retrovirus are observed in the cells of the rodents used most often for drug production.〔【出典】第十六改正日本薬局方（平成23年3月24日　厚生労働省告示第65号）〕

Although related terms might be found in different SOCs, they should be reviewed together for clinical relevance.〔【出典】ICHガイドライン 〕

To assess a medicine's sensitivity to ethnic factors it is important that there be knowledge of its pharmacokinetic and pharmacodynamic properties and the translation of those properties to clinical effectiveness and safety. A reasonable evaluation is described in Appendix C.〔【出典】ICHガイドライン 〕

There is clinical evidence to support his decision.

Firm evidence in support of claims requires that the results of the confirmatory trials demonstrate that the investigational product under test has clinical benefits.〔【出典】ICHガイドライン 〕

There have been many instances where treatments showing a highly positive effect on a proposed surrogate have ultimately been shown to be detrimental to the subjects' clinical outcome; conversely, there are cases of treatments conferring clinical benefit without measurable impact on proposed surrogates.〔【出典】ICHガイドライン 〕

This guideline applies to new chemical entities for human use and marketed pharmaceuticals when appropriate （e.g., when adverse clinical events, a new patient population, or a new route of administration raises concerns not previously addressed）.〔【出典】ICHガイドライン 〕

If there is evidence of a drug effect, any dose-response or drug concentration-response relationship or relationship to patient variables （e.g., disease, demographics, concomitant therapy） should be identified and the clinical relevance of the observation described.〔【出典】ICHガイドライン 〕