An alternative strategy would be to demonstrate the presence of unique markers, for example, by using banding cytogenetics to detect a unique marker chromosome, or DNA analysis to detect a genomic polymorphism pattern (for example, restriction fragment length polymorphism, variable number of tandem repeats, or genomic dinucleotide repeats).〔【出典】ICHガイドライン 〕
Restriction endonuclease mapping or other suitable techniques should be used to analyse the expression construct for copy number, for insertions or deletions, and for the number of integration sites.〔【出典】ICHガイドライン 〕